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1

In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei

Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Ōmura, Haruki Yamada

Journal:

Year:

2011

Language:

english

File:

PDF, 316 KB

english, 2011

2

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

Ishiyama, Aki, Otoguro, Kazuhiko, Iwatsuki, Masahito, Namatame, Miyuki, Nishihara, Aki, Nonaka, Kenichi, Kinoshita, Yuta, Takahashi, Yoko, Masuma, Rokuro, Shiomi, Kazuro

Journal:

The Journal of Antibiotics

Year:

2009

File:

PDF, 38 KB

2009

3

In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin

Ishiyama, Aki, Otoguro, Kazuhiko, Iwatsuki, Masahito, Namatame, Miyuki, Nishihara, Aki, Nonaka, Kenichi, Kinoshita, Yuta, Takahashi, Yoko, Masuma, Rokuro, Shiomi, Kazuro

Journal:

The Journal of Antibiotics

Year:

2009

Language:

english

File:

PDF, 173 KB

english, 2009

4

Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216

Nakashima, Takuji, Iwatsuki, Masato, Ochiai, Junya, Kamiya, Yoshiyuki, Nagai, Kenichiro, Matsumoto, Atsuko, Ishiyama, Aki, Otoguro, Kazuhiko, Shiomi, Kazuro, Takahashi, Yōko, Ōmura, Satoshi

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 1.56 MB

english, 2014

5

Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework

Yamada, Takeshi, Ideguchi-Matsushita, Tetsuya, Hirose, Tomoyasu, Shirahata, Tatsuya, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato, Sugawara, Akihiro, Kobayashi, Yoshinori, Otoguro, Kazuhiko, Ōmura, Sa

Journal:

Chemistry - A European Journal

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

6

In Vitro Antitrypanosomal Activity of the Secondary Metabolites from the Mutant Strain IU-3 of the Insect Pathogenic Fungus Ophiocordyceps coccidiicola NBRC 100683

Ganaha, Momoko, Yoshii, Kento, Ōtsuki, Yuuta, Iguchi, Miki, Okamoto, Yasuko, Iseki, Kanako, Ban, Sayaka, Ishiyama, Aki, Hokari, Rei, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Hashimoto, Tos

Year:

2016

Language:

english

File:

PDF, 402 KB

english, 2016

7

ChemInform Abstract: Merobatzelladines A (I) and B (II), Antiinfective Tricyclic Guanidines from a Marine Sponge Monanchora sp.

Shunsuke Takishima, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Haruki Yamada, Satoshi Omura, Hirotsugu Kobayashi, Rob W. M. van Soest, Shigeki Matsunaga

Journal:

Year:

2009

File:

PDF, 19 KB

2009

8

ChemInform Abstract: In vitro and in vivo Antiprotozoal Activities of Bispolides and Their Derivatives.

Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Seigo Sato, Masahiro Hatsu, Hironobu Iinuma, Seiji Shibahara, Satoshi Nimura, et al. et al.

Journal:

Year:

2010

File:

PDF, 15 KB

2010

9

Studies on the charge-transfer complex and polymerization, Part XVIII. Spontaneous polymerization of 2-vinylpyridine accompanying quaternization by methyl iodide

Shouji Iwatsuki, Takashi Kokubo, Kazuhiko Motomatsu, Morihiko Tsuji, Yuya Yamashita

Journal:

Macromolecular Chemistry and Physics

Year:

1968

Language:

english

File:

PDF, 298 KB

english, 1968

10

The relationship between surface tension and the industrial performance of water-soluble polymers prepared from acid hydrolysis lignin, a saccharification by-product from woody materials

Yasuyuki Matsushita, Masanori Imai, Ayuko Iwatsuki, Kazuhiko Fukushima

Journal:

Bioresource Technology

Year:

2008

Language:

english

File:

PDF, 132 KB

english, 2008

11

Comparison oflutjanus bengalensisfrom the western pacific with a related species,L. kasmira, and variations in both species (perciformes: Lutjanidae)

Yukio Iwatsuki, Tetsuo Yoshino, Kazuhiko Shimada

Journal:

Ichthyological Research

Year:

1999

Language:

english

File:

PDF, 718 KB

english, 1999

12

Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat

Reiko Meguro, Yoshiya Asano, Hiroyasu Iwatsuki, Kazuhiko Shoumura

Journal:

Histochemistry and Cell Biology

Year:

2003

Language:

english

File:

PDF, 1.00 MB

english, 2003

13

Visualization of non-heme ferric and ferrous iron by highly sensitive non-heme iron histochemistry in the stress-induced acute gastric lesions in the rat

Yoshiya Asano, Reiko Meguro, Saori Odagiri, Chentai Li, Hiroyasu Iwatsuki, Kazuhiko Shoumura

Journal:

Histochemistry and Cell Biology

Year:

2006

Language:

english

File:

PDF, 764 KB

english, 2006

14

Penicillium viticola, a new species isolated from a grape in Japan

Kenichi Nonaka, Rokuro Masuma, Masato Iwatsuki, Kazuro Shiomi, Kazuhiko Otoguro, Satoshi Ōmura

Journal:

Year:

2011

Language:

english

File:

PDF, 345 KB

english, 2011

15

In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A–C, produced by Penicillium sp. FKI-4410

Iwatsuki, Masato, Takada, Shohei, Mori, Mihoko, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tsukashima, Aki, Nonaka, Kenichi, Masuma, Rokuro, Otoguro, Kazuhiko, Shiomi, Kazuro

Journal:

The Journal of Antibiotics

Year:

2010

Language:

english

File:

PDF, 392 KB

english, 2010

16

In vitro and in vivo antiprotozoal activities of bispolides and their derivatives

Otoguro, Kazuhiko, Iwatsuki, Masato, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tsukashima, Aki, Sato, Seigo, Hatsu, Masahiro, Iinuma, Hironobu, Shibahara, Seiji, Nimura, Satoshi

Journal:

The Journal of Antibiotics

Year:

2010

Language:

english

File:

PDF, 167 KB

english, 2010

17

In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds

Otoguro, Kazuhiko, Ishiyama, Aki, Iwatsuki, Masato, Namatame, Miyuki, Nishihara-Tukashima, Aki, Nakashima, Takuji, Shibahara, Seiji, Kondo, Shinichi, Yamada, Haruki, Ōmura, Satoshi

Journal:

The Journal of Antibiotics

Year:

2010

Language:

english

File:

PDF, 175 KB

english, 2010

18

Promising lead compounds for novel antiprotozoals

Otoguro, Kazuhiko, Iwatsuki, Masato, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tukashima, Aki, Shibahara, Seiji, Kondo, Shinichi, Yamada, Haruki, Ōmura, Satoshi

Journal:

The Journal of Antibiotics

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

19

In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships

Iwatsuki, Masato, Otoguro, Kazuhiko, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tukashima, Aki, Hashida, Junko, Nakashima, Takuji, Masuma, Rokuro, Takahashi, Yoko, Yamada, Haruki

Journal:

The Journal of Antibiotics

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

20

Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum

Ishiyama, Aki, Iwatsuki, Masato, Namatame, Miyuki, Nishihara-Tsukashima, Aki, Sunazuka, Toshiaki, Takahashi, Yoko, Ōmura, Satoshi, Otoguro, Kazuhiko

Journal:

The Journal of Antibiotics

Year:

2011

Language:

english

File:

PDF, 279 KB

english, 2011

21

In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)

Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Ōmura, Haruki Yamada

Journal:

Journal of Natural Medicines

Year:

2012

Language:

english

File:

PDF, 199 KB

english, 2012

22

In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts againstTrypanosoma brucei

Kazuhiko Otoguro, Aki Ishiyama, Masato Iwatsuki, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Ōmura, Haruki Yamada

Journal:

Journal of Natural Medicines

Year:

2012

Language:

english

File:

PDF, 245 KB

english, 2012

23

Effects of human atrial natriuretic polypeptide on pancreatic exocrine secretion in the dog

Hisao Oguchi, Kazuhiko Iwatsuki, Akira Horiuchi, Seiichi Furuta, Shigetoshi Chiba

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 370 KB

english, 1987

24

l-dopa and pancreatic secretion

Koroku Hashimoto, Yasuhiko Furuta, Kazuhiko Iwatsuki

Journal:

Biochemical Pharmacology

Year:

1974

Language:

english

File:

PDF, 407 KB

english, 1974

25

Effect of propranolol on prolyl hydroxylase activity in blood vessels of rats

Kazuhiko Iwatsuki

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 397 KB

english, 1980

26

Effects of nitroprusside on pancreatic juice secretion in the blood-perfused canine pancreas

Kazuhiko Iwatsuki, Kenro Ikeda, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1982

Language:

english

File:

PDF, 512 KB

english, 1982

27

Effects of dopamine on exocrine secretion and cyclic nucleotide concentration in the dog pancreas

Fujio Iijima, Kazuhiko Iwatsuki, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1983

Language:

english

File:

PDF, 485 KB

english, 1983

28

Adenosine potentiates secretin-stimulated pancreatic exocrine secretion in the dog

Fujio Yamagishi, Norio Homma, Kohichi Haruta, Kazuhiko Iwatsuki, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 471 KB

english, 1985

29

Effects of nitroprusside on pancreatic exocrine secretion and cyclic nucleotide concentration in the dog pancreas

Kazuhiko Iwatsuki, Fujio Iijima, Fujio Yamagishi, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 224 KB

english, 1986

30

Effects of the cyclic nucleotide phosphodiesterase inhibitors, rolipram, 3-isobutyl-1-methylxanthine, amrinone and zaprinast, on pancreatic exocrine secretion in dogs

Kazuhiko Iwatsuki, Akira Horiuchi, Lei-Ming Ren, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 530 KB

english, 1991

31

Effects of YM435, a novel dopamine D1 receptor agonist, on pancreatic exocrine secretion in anesthetized dogs

Kazuhiko Iwatsuki, Lei-Ming Ren, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 465 KB

english, 1992

32

Dual actions of glucagon: direct stimulation and indirect inhibition of dog pancreatic secretion

Akira Horiuchi, Kazuhiko Iwatsuki, Lei-Ming Ren, Takai Kuroda, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 743 KB

english, 1993

33

Effects of KRN2391, a novel vasodilator, on pancreatic exocrine secretion in anesthetized dogs

Kazuhiko Iwatsuki, Akira Horiuchi, Lei-Ming Ren, Shigetoshi Chiba

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 523 KB

english, 1993

34

Intrastriatal targets of projection fibers from the central lateral nucleus of the rat thalamus

Noritaka Ichinohe, Hiroyasu Iwatsuki, Kazuhiko Shoumura

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 728 KB

english, 2001

35

‘In vivo perfusion Turnbull's reaction’ for Fe(II) histochemistry in non-anoxic/non-ischemic and anoxic/ischemic cat brains

Sungman Yu, Hiroyasu Iwatsuki, Noritaka Ichinohe, Fumiaki Mori, Kazuhiko Shoumura

Journal:

Neuroscience Letters

Year:

2001

Language:

english

File:

PDF, 643 KB

english, 2001

36

Changes in non-heme iron histochemistry in the ischemic brains of cats and Mongolian gerbils

Hiroyasu Iwatsuki, Reiko Meguro, Yoshiya Asano, Kazuhiko Shoumura

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 206 KB

english, 2003

37

Spoxazomicins A–C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T

Inahashi, Yuki, Iwatsuki, Masato, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tsukashima, Aki, Matsumoto, Atsuko, Hirose, Tomoyasu, Sunazuka, Toshiaki, Yamada, Haruki, Otoguro, Kazuhiko, Takahashi, Yōk

Journal:

The Journal of Antibiotics

Year:

2011

Language:

english

File:

PDF, 336 KB

english, 2011

38

Borrelidin analogues with antimalarial activity: Design, synthesis and biological evaluation against Plasmodium falciparum parasites

Sugawara, Akihiro, Tanaka, Toshiaki, Hirose, Tomoyasu, Ishiyama, Aki, Iwatsuki, Masato, Takahashi, Yoko, Otoguro, Kazuhiko, Ōmura, Satoshi, Sunazuka, Toshiaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 292 KB

english, 2013

39

Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry

Tsutsui, Ayumi, Hirose, Tomoyasu, Ishiyama, Aki, Iwatsuki, Masato, Yokota, Arisa, Maruyama, Hitomi, Matsui, Hidehito, Otoguro, Kazuhiko, Hanaki, Hideaki, Ōmura, Satoshi, Sunazuka, Toshiaki

Journal:

The Journal of Antibiotics

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

40

Structure Determination and Total Synthesis of (+)-16-Hydroxy-16,22-dihydroapparicine

Hirose, Tomoyasu, Noguchi, Yoshihiko, Furuya, Yujiro, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Sunazuka, Toshiaki

Journal:

Chemistry - A European Journal

Year:

2013

Language:

english

File:

PDF, 818 KB

english, 2013

41

Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine Sponge Monanchora sp.

Takishima, Shunsuke, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Yamada, Haruki, Õmura, Satoshi, Kobayashi, Hirotsugu, van Soest, Rob W. M., Matsunaga, Shigeki

Journal:

Organic Letters

Year:

2009

Language:

english

File:

PDF, 210 KB

english, 2009

42

In vitro antitrypanosomal activity of five low-MW antibiotics

Ishiyama, Aki, Otoguro, Kazuhiko, Iwatsuki, Masato, Namatame, Miyuki, Nishihara-Tsukashima, Aki, Takahashi, Yoko, Onodera, Hideyuki, Yamada, Haruki, Ōmura, Satoshi

Journal:

The Journal of Antibiotics

Year:

2012

Language:

english

File:

PDF, 151 KB

english, 2012

43

Semisynthesis of salviandulin E analogues and their antitrypanosomal activity

Aoyagi, Yutaka, Fujiwara, Koji, Yamazaki, Akira, Sugawara, Naoko, Yano, Reiko, Fukaya, Haruhiko, Hitotsuyanagi, Yukio, Takeya, Koichi, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Yamada, Haruk

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

44

Reduction of Blood Pressure and Vascular Collagen in Hypertensive Rats by β -aminopropionitrile

Kazuhiko Iwatsuki, George J. Cardinale, Sydney Spector and Sidney Udenfriend

Journal:

Proceedings of the National Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 682 KB

english, 1977

45

Three lanostane triterpenoids with antitrypanosomal activity from the fruiting body of Hexagonia tenuis

Umeyama, Akemi, Ohta, Chihiro, Shino, Yukari, Okada, Minori, Nakamura, Yukari, Hamagaki, Tatsuya, Imagawa, Hiroshi, Tanaka, Masami, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi,

Journal:

Year:

2014

Language:

english

File:

PDF, 401 KB

english, 2014

46

Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine Sponge Monanchora sp

Takishima, Shunsuke, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Yamada, Haruki, Õmura, Satoshi, Kobayashi, Hirotsugu, van Soest, Rob W. M., Matsunaga, Shigeki

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 26 KB

english, 2010

47

Antimalarial tropones and their Plasmodium falciparum glyoxalase I (pfGLOI) inhibitory activity

Ishiyama, Aki, Iwatsuki, Masato, Yamamoto, Tsuyoshi, Miura, Hiromi, Ōmura, Satoshi, Otoguro, Kazuhiko

Journal:

The Journal of Antibiotics

Year:

2014

Language:

english

File:

PDF, 196 KB

english, 2014

48

Actinoallolides A–E, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036

Inahashi, Yuki, Iwatsuki, Masato, Ishiyama, Aki, Matsumoto, Atsuko, Hirose, Tomoyasu, Oshita, Jun, Sunazuka, Toshiaki, Panbangred, Watanalai, Takahashi, Yoko, Kaiser, Marcel, Otoguro, Kazuhiko, O̅mura

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 765 KB

english, 2015

49

Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo

Ishiyama, Aki, Iwatsuki, Masato, Hokari, Rei, Sawa, Masaaki, Ōmura, Satoshi, Otoguro, Kazuhiko

Journal:

The Journal of Antibiotics

Year:

2015

Language:

english

File:

PDF, 244 KB

english, 2015

50

Inhibitory Action of Thyrotropin-Releasing Hormne on Serum Amylase Activity and Its Mechanism*

KOMIYA, ICHIRO, YAMADA, TAKASHI, KANNO, YUTAKA, AIZAWA, TORU, HASHIZUME, KIYOSHI, YAMAGISHI, FUJIO, IIJIMA, FUJIO, IWATSUKI, KAZUHIKO, CHIBA, SHIGEYTOSHI

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

1984

Language:

english

File:

PDF, 566 KB

english, 1984